Drug interactions
Capecitabine + Rabeprazole
Severity: Moderate
Capecitabine and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Observational data suggest that proton pump inhibitors may reduce the effectiveness of oral capecitabine, possibly through impaired tablet dissolution at higher gastric pH. The finding is inconsistent and the mechanism is not proven.
What this interaction means in plain words
Capecitabine and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH may reduce capecitabine dissolution and absorption, though the mechanism is not firmly established.
What to do
Review whether the PPI is needed and consider stopping or switching to an alternative acid-suppression strategy; monitor oncologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Rabeprazole?
MediHelp rates the interaction as moderate. Capecitabine and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Observational data suggest that proton pump inhibitors may reduce the effectiveness of oral capecitabine, possibly through impaired tablet dissolution at higher gastric pH. The finding is inconsistent and the mechanism is not proven.
How serious is the interaction between Capecitabine and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether the PPI is needed and consider stopping or switching to an alternative acid-suppression strategy; monitor oncologic response.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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