Drug interactions
Capreomycin + Cisatracurium
Severity: Major
Capreomycin and Cisatracurium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capreomycin has its own neuromuscular blocking activity and can potentiate and prolong the effect of cisatracurium. This may result in prolonged paralysis and respiratory failure.
What this interaction means in plain words
Capreomycin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nondepolarizing-type neuromuscular blockade from capreomycin at the neuromuscular junction.
What to do
Avoid if possible; otherwise reduce the cisatracurium dose and monitor with train-of-four, with ventilatory support available until full recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisatracurium
Frequently asked questions
Can I take Capreomycin with Cisatracurium?
MediHelp rates the interaction as major. Capreomycin and Cisatracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has its own neuromuscular blocking activity and can potentiate and prolong the effect of cisatracurium. This may result in prolonged paralysis and respiratory failure.
How serious is the interaction between Capreomycin and Cisatracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the cisatracurium dose and monitor with train-of-four, with ventilatory support available until full recovery.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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