Drug interactions
Capreomycin + Cyclosporin
Severity: Major
Capreomycin and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and capreomycin is also ototoxic and can cause electrolyte disturbances. Combined use may cause additive kidney injury, which in turn can raise capreomycin accumulation and toxicity.
What this interaction means in plain words
Capreomycin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity (and potential ototoxicity) from pharmacodynamic overlap.
What to do
Avoid the combination if alternatives exist; otherwise monitor serum creatinine, electrolytes (potassium, magnesium, calcium) and cyclosporine levels frequently, and assess hearing. Adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Capreomycin with Cyclosporin?
MediHelp rates the interaction as major. Capreomycin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and capreomycin is also ototoxic and can cause electrolyte disturbances. Combined use may cause additive kidney injury, which in turn can raise capreomycin accumulation and toxicity.
How serious is the interaction between Capreomycin and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist; otherwise monitor serum creatinine, electrolytes (potassium, magnesium, calcium) and cyclosporine levels frequently, and assess hearing. Adjust doses to renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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