Drug interactions
Capreomycin + Foscarnet
Severity: Major
Capreomycin and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are toxic to the kidneys, and capreomycin can also affect hearing and vestibular function. Together they increase the likelihood of renal impairment and electrolyte disturbances such as hypokalemia and hypomagnesemia.
What this interaction means in plain words
Capreomycin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity and electrolyte wasting from two renally toxic drugs.
What to do
Avoid concurrent use if alternatives exist. Otherwise monitor renal function, potassium, magnesium and calcium frequently and adjust doses to creatinine clearance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Capreomycin with Foscarnet?
MediHelp rates the interaction as major. Capreomycin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are toxic to the kidneys, and capreomycin can also affect hearing and vestibular function. Together they increase the likelihood of renal impairment and electrolyte disturbances such as hypokalemia and hypomagnesemia.
How serious is the interaction between Capreomycin and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist. Otherwise monitor renal function, potassium, magnesium and calcium frequently and adjust doses to creatinine clearance.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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