Drug interactions
Capreomycin + Neomycin
Severity: Major
Capreomycin and Neomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capreomycin is nephrotoxic, ototoxic and can cause neuromuscular blockade. Oral neomycin is poorly absorbed but may reach significant systemic levels with bowel inflammation or renal impairment, adding to toxicity.
What this interaction means in plain words
Capreomycin and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, ototoxicity and neuromuscular effects.
What to do
Avoid combination. If unavoidable, monitor renal function, electrolytes and hearing closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
- Gentamicin + Neomycin Major
Frequently asked questions
Can I take Capreomycin with Neomycin?
MediHelp rates the interaction as major. Capreomycin and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin is nephrotoxic, ototoxic and can cause neuromuscular blockade. Oral neomycin is poorly absorbed but may reach significant systemic levels with bowel inflammation or renal impairment, adding to toxicity.
How serious is the interaction between Capreomycin and Neomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination. If unavoidable, monitor renal function, electrolytes and hearing closely.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Cidofovir. The full list is on the Neomycin page.
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