Drug interactions
Ethacrynic acid + Neomycin
Severity: Major
Ethacrynic acid and Neomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the inner ear, and ethacrynic acid is especially associated with ototoxicity, sometimes irreversible. Oral neomycin is poorly absorbed, but systemic absorption can rise with bowel disease or renal impairment, increasing the risk.
What this interaction means in plain words
Ethacrynic acid and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Neomycin belongs to Anti Bacterial.
Why it happens
Additive cochlear toxicity, with volume depletion also increasing aminoglycoside nephrotoxicity.
What to do
Avoid the combination when possible and use an alternative diuretic. If needed, monitor renal function, hydration and audiometry.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Gentamicin + Neomycin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Neomycin?
MediHelp rates the interaction as major. Ethacrynic acid and Neomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the inner ear, and ethacrynic acid is especially associated with ototoxicity, sometimes irreversible. Oral neomycin is poorly absorbed, but systemic absorption can rise with bowel disease or renal impairment, increasing the risk.
How serious is the interaction between Ethacrynic acid and Neomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use an alternative diuretic. If needed, monitor renal function, hydration and audiometry.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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