Drug interactions
Capreomycin + Pancuronium
Severity: Major
Capreomycin and Pancuronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capreomycin has neuromuscular blocking activity and can potentiate and prolong pancuronium paralysis. This can cause delayed recovery and respiratory depression or apnea.
What this interaction means in plain words
Capreomycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Capreomycin has curare-like neuromuscular blocking action that adds to nondepolarizing blockade.
What to do
Avoid combining if possible; otherwise reduce pancuronium dose, monitor with train-of-four and keep ventilatory support available through recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pancuronium
Frequently asked questions
Can I take Capreomycin with Pancuronium?
MediHelp rates the interaction as major. Capreomycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has neuromuscular blocking activity and can potentiate and prolong pancuronium paralysis. This can cause delayed recovery and respiratory depression or apnea.
How serious is the interaction between Capreomycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; otherwise reduce pancuronium dose, monitor with train-of-four and keep ventilatory support available through recovery.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Clindamycin. The full list is on the Pancuronium page.
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