Drug interactions
Capsicum + Ramipril
Severity: Minor
Capsicum and Ramipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capsaicin-containing products can provoke cough, and ramipril commonly causes a dry cough through bradykinin and substance P accumulation. Using them together may make an ACE inhibitor cough more frequent or harder to attribute. The clinical effect is generally limited to symptom aggravation.
What this interaction means in plain words
Capsicum and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effect on sensory nerve-mediated cough pathways (substance P and bradykinin).
What to do
Ask patients with a new persistent cough about oral capsicum supplement use and stop the supplement first to see if the cough resolves. Switch to an ARB only if the cough continues and is bothersome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Capsicum with Ramipril?
MediHelp rates the interaction as minor. Capsicum and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capsaicin-containing products can provoke cough, and ramipril commonly causes a dry cough through bradykinin and substance P accumulation. Using them together may make an ACE inhibitor cough more frequent or harder to attribute. The clinical effect is generally limited to symptom aggravation.
How serious is the interaction between Capsicum and Ramipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients with a new persistent cough about oral capsicum supplement use and stop the supplement first to see if the cough resolves. Switch to an ARB only if the cough continues and is bothersome.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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