Drug interactions
Captopril + Carbidopa-levodopa
Severity: Moderate
Captopril and Carbidopa-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both levodopa and captopril lower blood pressure, so combined use can cause additive hypotension and orthostatic symptoms. Falls and syncope are a concern, particularly in older patients.
What this interaction means in plain words
Captopril and Carbidopa-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Carbidopa-levodopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects of levodopa and ACE inhibition.
What to do
Monitor blood pressure, including standing readings, when starting or changing either drug. Lower the captopril dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Carbidopa-levodopa?
MediHelp rates the interaction as moderate. Captopril and Carbidopa-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both levodopa and captopril lower blood pressure, so combined use can cause additive hypotension and orthostatic symptoms. Falls and syncope are a concern, particularly in older patients.
How serious is the interaction between Captopril and Carbidopa-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or changing either drug. Lower the captopril dose if symptomatic hypotension develops.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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