Drug interactions
Captopril + Clozapine
Severity: Moderate
Captopril and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine frequently causes orthostatic hypotension and syncope, which may be intensified by an ACE inhibitor. The risk is greatest during clozapine dose titration.
What this interaction means in plain words
Captopril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Clozapine belongs to Central Nervous System.
Why it happens
Additive hypotension from clozapine alpha-1 adrenergic blockade and captopril ACE inhibition.
What to do
Monitor supine and standing blood pressure, especially during clozapine titration. Adjust the antihypertensive dose if orthostasis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Captopril with Clozapine?
MediHelp rates the interaction as moderate. Captopril and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine frequently causes orthostatic hypotension and syncope, which may be intensified by an ACE inhibitor. The risk is greatest during clozapine dose titration.
How serious is the interaction between Captopril and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure, especially during clozapine titration. Adjust the antihypertensive dose if orthostasis occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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