Drug interactions
Captopril + Desvenlafaxine
Severity: Minor
Captopril and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril is only partly metabolized and CYP2D6 is not a clinically important route for its clearance, so a meaningful pharmacokinetic interaction is not expected. Desvenlafaxine may modestly raise blood pressure, which could marginally oppose captopril, but this is not a well-established effect.
What this interaction means in plain words
Captopril and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Desvenlafaxine belongs to Central Nervous System.
Why it happens
No established mechanism; the CYP2D6 inhibition by desvenlafaxine is of little relevance to captopril.
What to do
No dose change is needed. Monitor blood pressure routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Captopril with Desvenlafaxine?
MediHelp rates the interaction as minor. Captopril and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Captopril is only partly metabolized and CYP2D6 is not a clinically important route for its clearance, so a meaningful pharmacokinetic interaction is not expected. Desvenlafaxine may modestly raise blood pressure, which could marginally oppose captopril, but this is not a well-established effect.
How serious is the interaction between Captopril and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood pressure routinely.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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