Drug interactions
Captopril + Drospirenone
Severity: Moderate
Captopril and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and ACE inhibitors also promote potassium retention. Together they increase the risk of hyperkalemia, especially with renal impairment.
What this interaction means in plain words
Captopril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from aldosterone antagonism by drospirenone and reduced aldosterone from ACE inhibition.
What to do
Check serum potassium during the first cycle of co-therapy and periodically afterward. Choose a different contraceptive if hyperkalemia or renal impairment is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Captopril with Drospirenone?
MediHelp rates the interaction as moderate. Captopril and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and ACE inhibitors also promote potassium retention. Together they increase the risk of hyperkalemia, especially with renal impairment.
How serious is the interaction between Captopril and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of co-therapy and periodically afterward. Choose a different contraceptive if hyperkalemia or renal impairment is present.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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