Drug interactions
Captopril + Empagliflozin-metformin
Severity: Moderate
Captopril and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity, occasionally causing hypoglycemia in patients on antidiabetic drugs. Renal function decline from ACE inhibition can also impair metformin clearance and raise lactic acidosis risk, and volume depletion with empagliflozin adds to renal risk.
What this interaction means in plain words
Captopril and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity and alter renal hemodynamics, reducing metformin clearance if renal function falls.
What to do
Monitor renal function, volume status and glucose when starting or adjusting captopril. Stop metformin if acute kidney injury or eGFR below labeled limits occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Captopril and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity, occasionally causing hypoglycemia in patients on antidiabetic drugs. Renal function decline from ACE inhibition can also impair metformin clearance and raise lactic acidosis risk, and volume depletion with empagliflozin adds to renal risk.
How serious is the interaction between Captopril and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, volume status and glucose when starting or adjusting captopril. Stop metformin if acute kidney injury or eGFR below labeled limits occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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