Drug interactions
Captopril + Enoxaparin
Severity: Moderate
Captopril and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin may suppress aldosterone secretion and, with an ACE inhibitor, can cause hyperkalemia. The risk is greater with renal impairment, diabetes or prolonged therapy.
What this interaction means in plain words
Captopril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone leading to reduced renal potassium excretion.
What to do
Monitor serum potassium and renal function, particularly if enoxaparin is given for more than a few days. Manage hyperkalemia and review other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Captopril with Enoxaparin?
MediHelp rates the interaction as moderate. Captopril and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin may suppress aldosterone secretion and, with an ACE inhibitor, can cause hyperkalemia. The risk is greater with renal impairment, diabetes or prolonged therapy.
How serious is the interaction between Captopril and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly if enoxaparin is given for more than a few days. Manage hyperkalemia and review other potassium-raising drugs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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