Drug interactions
Captopril + Gliclazide
Severity: Minor
Captopril and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril may enhance insulin sensitivity and increase the hypoglycemic effect of gliclazide. Episodes of hypoglycemia are uncommon but have been described, particularly early in therapy.
What this interaction means in plain words
Captopril and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Monitor blood glucose after starting captopril and educate the patient on hypoglycemia. Reduce the gliclazide dose if low glucose readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Gliclazide?
MediHelp rates the interaction as minor. Captopril and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Captopril may enhance insulin sensitivity and increase the hypoglycemic effect of gliclazide. Episodes of hypoglycemia are uncommon but have been described, particularly early in therapy.
How serious is the interaction between Captopril and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting captopril and educate the patient on hypoglycemia. Reduce the gliclazide dose if low glucose readings occur.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
