Drug interactions
Captopril + Glipizide-metformin
Severity: Moderate
Captopril and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and enhance the hypoglycemic effect of glipizide and metformin. Hypoglycemia is most likely early after starting the ACE inhibitor.
What this interaction means in plain words
Captopril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, producing additive glucose lowering.
What to do
Monitor blood glucose when starting captopril and reduce the glipizide dose if hypoglycemia occurs. Monitor renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Glipizide-metformin?
MediHelp rates the interaction as moderate. Captopril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and enhance the hypoglycemic effect of glipizide and metformin. Hypoglycemia is most likely early after starting the ACE inhibitor.
How serious is the interaction between Captopril and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting captopril and reduce the glipizide dose if hypoglycemia occurs. Monitor renal function.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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