Drug interactions
Captopril + Glyburide-metformin
Severity: Moderate
Captopril and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as captopril may enhance insulin sensitivity and potentiate the glucose-lowering effect of sulfonylureas and metformin, occasionally causing hypoglycemia. Renal impairment related to ACE inhibition may also raise metformin levels.
What this interaction means in plain words
Captopril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Improved insulin sensitivity adds to antidiabetic effect; renal effects may alter metformin clearance.
What to do
Monitor blood glucose when starting captopril and reduce the glyburide dose if hypoglycemia occurs. Monitor renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Glyburide-metformin?
MediHelp rates the interaction as moderate. Captopril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as captopril may enhance insulin sensitivity and potentiate the glucose-lowering effect of sulfonylureas and metformin, occasionally causing hypoglycemia. Renal impairment related to ACE inhibition may also raise metformin levels.
How serious is the interaction between Captopril and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting captopril and reduce the glyburide dose if hypoglycemia occurs. Monitor renal function periodically.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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