Drug interactions
Captopril + Imipramine
Severity: Moderate
Captopril and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can cause orthostatic hypotension through alpha-adrenergic blockade, and this may add to the antihypertensive effect of captopril. Falls and dizziness are a concern, especially in older patients.
What this interaction means in plain words
Captopril and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from tricyclic alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure including standing readings after starting or changing doses. Lower the dose of one agent if orthostatic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril with Imipramine?
MediHelp rates the interaction as moderate. Captopril and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can cause orthostatic hypotension through alpha-adrenergic blockade, and this may add to the antihypertensive effect of captopril. Falls and dizziness are a concern, especially in older patients.
How serious is the interaction between Captopril and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings after starting or changing doses. Lower the dose of one agent if orthostatic symptoms appear.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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