Drug interactions
Captopril + Insulin degludec-liraglutide
Severity: Moderate
Captopril and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as captopril may increase insulin sensitivity and enhance glucose lowering with insulin and liraglutide. Hypoglycemia can occur, particularly early in ACE inhibitor therapy.
What this interaction means in plain words
Captopril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor glucose closely during the first weeks after starting captopril and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Captopril and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as captopril may increase insulin sensitivity and enhance glucose lowering with insulin and liraglutide. Hypoglycemia can occur, particularly early in ACE inhibitor therapy.
How serious is the interaction between Captopril and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely during the first weeks after starting captopril and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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