Drug interactions
Captopril + Isoflurane
Severity: Moderate
Captopril and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane causes vasodilation and myocardial depression, and patients taking ACE inhibitors are more prone to marked hypotension during anesthesia. The hypotension may be refractory to standard vasopressors.
What this interaction means in plain words
Captopril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation; inhaled anesthetic effects combine with loss of angiotensin II-mediated vascular tone.
What to do
Monitor blood pressure closely during induction and maintenance, and treat hypotension with fluids and vasopressors. Consider omitting the ACE inhibitor on the morning of surgery per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Captopril with Isoflurane?
MediHelp rates the interaction as moderate. Captopril and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane causes vasodilation and myocardial depression, and patients taking ACE inhibitors are more prone to marked hypotension during anesthesia. The hypotension may be refractory to standard vasopressors.
How serious is the interaction between Captopril and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during induction and maintenance, and treat hypotension with fluids and vasopressors. Consider omitting the ACE inhibitor on the morning of surgery per local protocol.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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