Drug interactions
Captopril + Rasagiline
Severity: Minor
Captopril and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline can cause orthostatic hypotension and may add to the blood pressure lowering of captopril. The effect is usually modest.
What this interaction means in plain words
Captopril and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
Additive hypotensive effects; rasagiline's contribution is through autonomic effects that are not fully defined.
What to do
Monitor blood pressure and orthostatic symptoms after starting rasagiline. Reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Captopril with Rasagiline?
MediHelp rates the interaction as minor. Captopril and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rasagiline can cause orthostatic hypotension and may add to the blood pressure lowering of captopril. The effect is usually modest.
How serious is the interaction between Captopril and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms after starting rasagiline. Reduce the antihypertensive dose if symptomatic.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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