Drug interactions
Captopril + Selegiline
Severity: Minor
Captopril and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline can cause orthostatic hypotension, particularly in Parkinson disease patients, and this may be additive with captopril. The effect is usually modest at low oral doses.
What this interaction means in plain words
Captopril and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
Why it happens
Additive hypotensive effects, with selegiline contributing through autonomic effects.
What to do
Monitor blood pressure and orthostatic symptoms after starting selegiline. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Captopril with Selegiline?
MediHelp rates the interaction as minor. Captopril and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selegiline can cause orthostatic hypotension, particularly in Parkinson disease patients, and this may be additive with captopril. The effect is usually modest at low oral doses.
How serious is the interaction between Captopril and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms after starting selegiline. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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