Drug interactions
Carbachol + Darifenacin
Severity: Moderate
Carbachol and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist and darifenacin is a muscarinic antagonist, so they oppose each other's effects. Darifenacin may reduce the effect of carbachol at muscarinic receptors.
What this interaction means in plain words
Carbachol and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbachol belongs to Miscellaneous; Darifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced effect of carbachol, such as reduced miosis or intraocular pressure lowering. Consider an alternative if the therapeutic effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
- Carbachol + Galantamine Moderate
Frequently asked questions
Can I take Carbachol with Darifenacin?
MediHelp rates the interaction as moderate. Carbachol and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbachol is a cholinergic agonist and darifenacin is a muscarinic antagonist, so they oppose each other's effects. Darifenacin may reduce the effect of carbachol at muscarinic receptors.
How serious is the interaction between Carbachol and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced effect of carbachol, such as reduced miosis or intraocular pressure lowering. Consider an alternative if the therapeutic effect is lost.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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