Drug interactions
Atropine + Carbachol
Severity: Moderate
Atropine and Carbachol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine blocks muscarinic receptors that carbachol stimulates, so the two have opposing effects. Atropine can reduce the pupil constriction and intraocular pressure lowering of carbachol, and is also used to counter carbachol toxicity.
What this interaction means in plain words
Atropine and Carbachol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Carbachol belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid combining them unless intended, since efficacy of carbachol will be reduced. Monitor the therapeutic response, and have atropine available to treat cholinergic excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Carbachol
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
- Carbachol + Galantamine Moderate
Frequently asked questions
Can I take Atropine with Carbachol?
MediHelp rates the interaction as moderate. Atropine and Carbachol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine blocks muscarinic receptors that carbachol stimulates, so the two have opposing effects. Atropine can reduce the pupil constriction and intraocular pressure lowering of carbachol, and is also used to counter carbachol toxicity.
How serious is the interaction between Atropine and Carbachol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them unless intended, since efficacy of carbachol will be reduced. Monitor the therapeutic response, and have atropine available to treat cholinergic excess.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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