Drug interactions
Carbenoxolone + Dobutamine
Severity: Moderate
Carbenoxolone and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss, and dobutamine can further lower serum potassium by driving it into cells. The combination may cause hypokalemia and increase the risk of arrhythmia.
What this interaction means in plain words
Carbenoxolone and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium lowering through renal potassium wasting (carbenoxolone) and beta-2 mediated cellular uptake (dobutamine).
What to do
Check serum potassium before and during dobutamine therapy and replace potassium as needed. Monitor the ECG in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Carbenoxolone with Dobutamine?
MediHelp rates the interaction as moderate. Carbenoxolone and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss, and dobutamine can further lower serum potassium by driving it into cells. The combination may cause hypokalemia and increase the risk of arrhythmia.
How serious is the interaction between Carbenoxolone and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before and during dobutamine therapy and replace potassium as needed. Monitor the ECG in patients with cardiac disease.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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