Drug interactions
Dihydroergotamine + Dobutamine
Severity: Major
Dihydroergotamine and Dobutamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes potent peripheral vasoconstriction, and dobutamine adds adrenergic cardiovascular stimulation with variable vascular effects. Together they may increase blood pressure and risk of ischemia. Risk is mostly predicted from pharmacology.
What this interaction means in plain words
Dihydroergotamine and Dobutamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Dobutamine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasoconstriction and cardiovascular stimulation.
What to do
Avoid combining where possible and monitor blood pressure and peripheral perfusion continuously if unavoidable. Reduce the dobutamine rate if hypertension or ischemic signs appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dobutamine
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Dobutamine?
MediHelp rates the interaction as major. Dihydroergotamine and Dobutamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine causes potent peripheral vasoconstriction, and dobutamine adds adrenergic cardiovascular stimulation with variable vascular effects. Together they may increase blood pressure and risk of ischemia. Risk is mostly predicted from pharmacology.
How serious is the interaction between Dihydroergotamine and Dobutamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and monitor blood pressure and peripheral perfusion continuously if unavoidable. Reduce the dobutamine rate if hypertension or ischemic signs appear.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Ergotamine. The full list is on the Dobutamine page.
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