Drug interactions
Carbenoxolone + Drospirenone
Severity: Minor
Carbenoxolone and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing potassium loss and sodium retention, opposing drospirenone's antimineralocorticoid action. The combination may reduce the effect of either and cause fluid retention or blood pressure changes.
What this interaction means in plain words
Carbenoxolone and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing mineralocorticoid effects on renal potassium and sodium handling.
What to do
Monitor serum potassium and blood pressure during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Drospirenone
Frequently asked questions
Can I take Carbenoxolone with Drospirenone?
MediHelp rates the interaction as minor. Carbenoxolone and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbenoxolone has mineralocorticoid-like effects causing potassium loss and sodium retention, opposing drospirenone's antimineralocorticoid action. The combination may reduce the effect of either and cause fluid retention or blood pressure changes.
How serious is the interaction between Carbenoxolone and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during combined use.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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