Drug interactions
Carbenoxolone + Eprosartan-hydrochlorothiazide
Severity: Major
Carbenoxolone and Eprosartan-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia. It can also raise blood pressure and oppose antihypertensive therapy.
What this interaction means in plain words
Carbenoxolone and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing mineralocorticoid-like potassium wasting and fluid retention that adds to thiazide effects.
What to do
Avoid the combination where possible. If used, monitor serum potassium and blood pressure frequently and replace potassium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Carbenoxolone with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Carbenoxolone and Eprosartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia. It can also raise blood pressure and oppose antihypertensive therapy.
How serious is the interaction between Carbenoxolone and Eprosartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor serum potassium and blood pressure frequently and replace potassium as needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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