Drug interactions
Carbenoxolone + Eprosartan
Severity: Moderate
Carbenoxolone and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention, hypokalemia and hypertension through mineralocorticoid-like effects, which opposes eprosartan's blood-pressure-lowering action. Potassium effects are opposing and unpredictable.
What this interaction means in plain words
Carbenoxolone and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase produces mineralocorticoid excess, causing fluid retention and potassium loss that oppose angiotensin receptor blockade.
What to do
Monitor blood pressure, serum potassium and fluid status. Consider stopping carbenoxolone if hypertension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Carbenoxolone with Eprosartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention, hypokalemia and hypertension through mineralocorticoid-like effects, which opposes eprosartan's blood-pressure-lowering action. Potassium effects are opposing and unpredictable.
How serious is the interaction between Carbenoxolone and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and fluid status. Consider stopping carbenoxolone if hypertension or edema develops.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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