Drug interactions
Carbenoxolone + Flurbiprofen
Severity: Moderate
Carbenoxolone and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention, hypertension and hypokalemia, and NSAIDs can add fluid retention and blunt blood pressure control. Potassium effects oppose each other but the combined fluid effects can matter.
What this interaction means in plain words
Carbenoxolone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid-like activity, and NSAID prostaglandin inhibition adds sodium and water retention.
What to do
Monitor blood pressure, edema and serum potassium during combined use. Consider alternatives if fluid retention or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Carbenoxolone with Flurbiprofen?
MediHelp rates the interaction as moderate. Carbenoxolone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention, hypertension and hypokalemia, and NSAIDs can add fluid retention and blunt blood pressure control. Potassium effects oppose each other but the combined fluid effects can matter.
How serious is the interaction between Carbenoxolone and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium during combined use. Consider alternatives if fluid retention or hypertension develops.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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