Drug interactions
Carbenoxolone + Fluticasone-salmeterol
Severity: Moderate
Carbenoxolone and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss and sodium retention. Salmeterol can also lower serum potassium by driving potassium into cells, so combined use may produce clinically relevant hypokalemia, particularly at higher beta-agonist doses or in patients with other risk factors. Hypokalemia can predispose to arrhythmias.
What this interaction means in plain words
Carbenoxolone and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia: renal potassium wasting from carbenoxolone plus beta-2-mediated intracellular potassium shift from salmeterol.
What to do
Monitor serum potassium, especially at treatment start and in patients with cardiac disease. Replace potassium as needed and consider stopping carbenoxolone if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Carbenoxolone with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Carbenoxolone and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss and sodium retention. Salmeterol can also lower serum potassium by driving potassium into cells, so combined use may produce clinically relevant hypokalemia, particularly at higher beta-agonist doses or in patients with other risk factors. Hypokalemia can predispose to arrhythmias.
How serious is the interaction between Carbenoxolone and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at treatment start and in patients with cardiac disease. Replace potassium as needed and consider stopping carbenoxolone if hypokalemia develops.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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