Drug interactions
Carbenoxolone + Naproxen
Severity: Moderate
Carbenoxolone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and water retention with potassium loss, while NSAIDs also cause fluid retention and may blunt blood pressure control. The combination may worsen hypertension, oedema and heart failure.
What this interaction means in plain words
Carbenoxolone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mineralocorticoid-like effect of carbenoxolone adds to NSAID-induced renal sodium and water retention.
What to do
Monitor blood pressure, fluid status and serum potassium during concurrent use. Consider an alternative to one of the agents in patients with hypertension or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbenoxolone and Naproxen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Carbenoxolone with Naproxen?
MediHelp rates the interaction as moderate. Carbenoxolone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and water retention with potassium loss, while NSAIDs also cause fluid retention and may blunt blood pressure control. The combination may worsen hypertension, oedema and heart failure.
How serious is the interaction between Carbenoxolone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during concurrent use. Consider an alternative to one of the agents in patients with hypertension or heart failure.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
