Drug interactions
Carbenoxolone + Propranolol
Severity: Moderate
Carbenoxolone and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects. This may raise blood pressure, oppose propranolol, and increase arrhythmia risk through hypokalemia.
What this interaction means in plain words
Carbenoxolone and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing mineralocorticoid excess, fluid retention and hypokalemia.
What to do
Monitor blood pressure and serum potassium during combined use and correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Carbenoxolone with Propranolol?
MediHelp rates the interaction as moderate. Carbenoxolone and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects. This may raise blood pressure, oppose propranolol, and increase arrhythmia risk through hypokalemia.
How serious is the interaction between Carbenoxolone and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during combined use and correct hypokalemia promptly.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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