Drug interactions
Carbenoxolone + Sacubitril-valsartan
Severity: Moderate
Carbenoxolone and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium and water retention and potassium loss, which can oppose antihypertensive therapy and cause hypertension and edema. Its effect on potassium partly offsets valsartan.
What this interaction means in plain words
Carbenoxolone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase produces mineralocorticoid-like sodium retention and potassium wasting.
What to do
Avoid in heart failure or hypertension where possible. If used, monitor blood pressure, weight, edema and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Carbenoxolone with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that causes sodium and water retention and potassium loss, which can oppose antihypertensive therapy and cause hypertension and edema. Its effect on potassium partly offsets valsartan.
How serious is the interaction between Carbenoxolone and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in heart failure or hypertension where possible. If used, monitor blood pressure, weight, edema and electrolytes.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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