Drug interactions
Carbenoxolone + Salbutamol
Severity: Moderate
Carbenoxolone and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss, and salbutamol shifts potassium into cells. Together they can produce clinically significant hypokalemia and raise arrhythmia risk.
What this interaction means in plain words
Carbenoxolone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Renal potassium wasting from carbenoxolone combined with beta-2 agonist-induced intracellular potassium shift.
What to do
Monitor serum potassium, particularly with high-dose or nebulised salbutamol, and supplement potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Carbenoxolone with Salbutamol?
MediHelp rates the interaction as moderate. Carbenoxolone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss, and salbutamol shifts potassium into cells. Together they can produce clinically significant hypokalemia and raise arrhythmia risk.
How serious is the interaction between Carbenoxolone and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with high-dose or nebulised salbutamol, and supplement potassium if low.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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