Drug interactions
Carbenoxolone + Salmeterol
Severity: Moderate
Carbenoxolone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes potassium loss, and salmeterol can further lower serum potassium. Combined use may cause hypokalemia with a risk of arrhythmias and muscle weakness.
What this interaction means in plain words
Carbenoxolone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from renal potassium wasting and beta-2 mediated cellular potassium uptake.
What to do
Monitor serum potassium regularly and supplement if needed. Consider an alternative if hypokalemia is difficult to control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Carbenoxolone with Salmeterol?
MediHelp rates the interaction as moderate. Carbenoxolone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that causes potassium loss, and salmeterol can further lower serum potassium. Combined use may cause hypokalemia with a risk of arrhythmias and muscle weakness.
How serious is the interaction between Carbenoxolone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement if needed. Consider an alternative if hypokalemia is difficult to control.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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