Drug interactions
Carbenoxolone + Spironolactone
Severity: Moderate
Carbenoxolone and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss, directly opposing spironolactone. The combination reduces the efficacy of spironolactone and can worsen hypertension and edema.
What this interaction means in plain words
Carbenoxolone and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid effects that antagonize spironolactone's receptor blockade.
What to do
Avoid the combination where possible; if used, monitor blood pressure, fluid status and serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Carbenoxolone with Spironolactone?
MediHelp rates the interaction as moderate. Carbenoxolone and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss, directly opposing spironolactone. The combination reduces the efficacy of spironolactone and can worsen hypertension and edema.
How serious is the interaction between Carbenoxolone and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor blood pressure, fluid status and serum potassium.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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