Drug interactions
Carbenoxolone + Timolol
Severity: Moderate
Carbenoxolone and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention and potassium loss and can raise blood pressure, which may counteract the antihypertensive effect of timolol. Hypokalemia may also be clinically relevant in cardiac patients.
What this interaction means in plain words
Carbenoxolone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid-like activity that causes fluid retention, hypertension and potassium wasting, opposing beta-blocker therapy.
What to do
Monitor blood pressure and serum potassium during combined use, and correct hypokalemia or choose an alternative to carbenoxolone if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Carbenoxolone with Timolol?
MediHelp rates the interaction as moderate. Carbenoxolone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention and potassium loss and can raise blood pressure, which may counteract the antihypertensive effect of timolol. Hypokalemia may also be clinically relevant in cardiac patients.
How serious is the interaction between Carbenoxolone and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during combined use, and correct hypokalemia or choose an alternative to carbenoxolone if hypertension develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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