Drug interactions
Carbenoxolone + Tolmetin
Severity: Moderate
Carbenoxolone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects, while NSAIDs also cause fluid retention. Together they may worsen hypertension and edema, with unpredictable potassium effects.
What this interaction means in plain words
Carbenoxolone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase causing mineralocorticoid excess, with additive NSAID sodium and water retention.
What to do
Monitor blood pressure, edema and serum potassium. Consider an alternative to one of the agents in patients with hypertension or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Carbenoxolone with Tolmetin?
MediHelp rates the interaction as moderate. Carbenoxolone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects, while NSAIDs also cause fluid retention. Together they may worsen hypertension and edema, with unpredictable potassium effects.
How serious is the interaction between Carbenoxolone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium. Consider an alternative to one of the agents in patients with hypertension or heart failure.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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