Drug interactions
Carbenoxolone + Triamterene
Severity: Moderate
Carbenoxolone and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium retention and potassium loss, whereas triamterene spares potassium. The combination opposes this effect and may reduce hypokalemia, but it also reduces the diuretic effect.
What this interaction means in plain words
Carbenoxolone and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone causes mineralocorticoid-like sodium retention and potassium loss, opposed by triamterene's ENaC blockade.
What to do
Monitor serum potassium, blood pressure and fluid status. Expect variable diuretic effect and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbenoxolone and Triamterene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Carbenoxolone with Triamterene?
MediHelp rates the interaction as moderate. Carbenoxolone and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium retention and potassium loss, whereas triamterene spares potassium. The combination opposes this effect and may reduce hypokalemia, but it also reduces the diuretic effect.
How serious is the interaction between Carbenoxolone and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, blood pressure and fluid status. Expect variable diuretic effect and adjust doses accordingly.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
