Drug interactions
Carbenoxolone + Valsartan
Severity: Moderate
Carbenoxolone and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypokalemia and raised blood pressure. This can antagonize valsartan's antihypertensive effect, while potassium effects may partly offset each other.
What this interaction means in plain words
Carbenoxolone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing mineralocorticoid excess that opposes ARB effects.
What to do
Monitor blood pressure, fluid status and serum potassium. Consider an alternative to carbenoxolone if hypertension worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Carbenoxolone with Valsartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypokalemia and raised blood pressure. This can antagonize valsartan's antihypertensive effect, while potassium effects may partly offset each other.
How serious is the interaction between Carbenoxolone and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium. Consider an alternative to carbenoxolone if hypertension worsens.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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