Drug interactions
Carbidopa-entacapone-levodopa + Clozapine
Severity: Moderate
Carbidopa-entacapone-levodopa and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has weak D2 blockade and is generally used in Parkinson's disease psychosis, so antagonism of levodopa is minimal. Both can contribute to additive orthostatic hypotension and sedation.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Weak dopamine antagonism with additive hypotensive and sedative effects.
What to do
Use low clozapine doses with standard hematologic monitoring. Monitor orthostatic blood pressure and motor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Clozapine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has weak D2 blockade and is generally used in Parkinson's disease psychosis, so antagonism of levodopa is minimal. Both can contribute to additive orthostatic hypotension and sedation.
How serious is the interaction between Carbidopa-entacapone-levodopa and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low clozapine doses with standard hematologic monitoring. Monitor orthostatic blood pressure and motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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