Drug interactions
Carbidopa-entacapone-levodopa + Dobutamine
Severity: Moderate
Carbidopa-entacapone-levodopa and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone inhibits catechol-O-methyltransferase, one of the enzymes that clears dobutamine, a catecholamine. Exposure to dobutamine may therefore be prolonged or increased, with a risk of exaggerated tachycardia, arrhythmias and blood pressure changes.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Dobutamine belongs to Cardiovascular.
Why it happens
Entacapone inhibits COMT-mediated methylation of catecholamines, reducing dobutamine clearance.
What to do
Titrate dobutamine cautiously and monitor heart rate, rhythm and blood pressure continuously during the infusion. Lower the infusion rate if tachyarrhythmia or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Dobutamine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entacapone inhibits catechol-O-methyltransferase, one of the enzymes that clears dobutamine, a catecholamine. Exposure to dobutamine may therefore be prolonged or increased, with a risk of exaggerated tachycardia, arrhythmias and blood pressure changes.
How serious is the interaction between Carbidopa-entacapone-levodopa and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dobutamine cautiously and monitor heart rate, rhythm and blood pressure continuously during the infusion. Lower the infusion rate if tachyarrhythmia or hypertension develops.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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