Drug interactions
Carbidopa-entacapone-levodopa + Fesoterodine
Severity: Minor
Carbidopa-entacapone-levodopa and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine has antimuscarinic effects that could slow gastric emptying and slightly reduce levodopa absorption, and may add to confusion or constipation. Clinical significance is generally small.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Antimuscarinic delay of gastric emptying may increase gastric degradation of levodopa; effects are largely theoretical.
What to do
Monitor for changes in Parkinson symptom control, cognition and constipation after starting fesoterodine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Fesoterodine
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Fesoterodine?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fesoterodine has antimuscarinic effects that could slow gastric emptying and slightly reduce levodopa absorption, and may add to confusion or constipation. Clinical significance is generally small.
How serious is the interaction between Carbidopa-entacapone-levodopa and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in Parkinson symptom control, cognition and constipation after starting fesoterodine.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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