Drug interactions
Carbidopa-entacapone-levodopa + Lumateperone
Severity: Moderate
Carbidopa-entacapone-levodopa and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone is metabolized by CYP3A4, and inhibitors increase exposure with greater sedation and adverse effects. Entacapone is not a recognized clinically relevant CYP3A4 inhibitor. In addition, antipsychotics oppose levodopa's dopaminergic effect and can worsen parkinsonism.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Pharmacodynamic dopamine antagonism by lumateperone versus levodopa, with a theoretical minor CYP3A4 effect.
What to do
Monitor motor function in Parkinson's disease and for sedation or orthostasis. Use lumateperone with particular care in this population because it can worsen motor symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Lumateperone?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumateperone is metabolized by CYP3A4, and inhibitors increase exposure with greater sedation and adverse effects. Entacapone is not a recognized clinically relevant CYP3A4 inhibitor. In addition, antipsychotics oppose levodopa's dopaminergic effect and can worsen parkinsonism.
How serious is the interaction between Carbidopa-entacapone-levodopa and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function in Parkinson's disease and for sedation or orthostasis. Use lumateperone with particular care in this population because it can worsen motor symptoms.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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