Drug interactions
Carbamazepine + Lumateperone
Severity: Major
Carbamazepine and Lumateperone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine markedly reduces lumateperone exposure, likely causing loss of antipsychotic effect.
What this interaction means in plain words
Carbamazepine and Lumateperone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, the main metabolic pathway for lumateperone.
What to do
Avoid co-administration per labeling and select an alternative that is not CYP3A4 dependent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Carbamazepine with Lumateperone?
MediHelp rates the interaction as major. Carbamazepine and Lumateperone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine markedly reduces lumateperone exposure, likely causing loss of antipsychotic effect.
How serious is the interaction between Carbamazepine and Lumateperone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration per labeling and select an alternative that is not CYP3A4 dependent.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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