Drug interactions
Carbidopa-entacapone-levodopa + Mavacamten
Severity: Minor
Carbidopa-entacapone-levodopa and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared by CYP2C19 and CYP3A4, and increased exposure can excessively reduce ejection fraction and cause heart failure. Entacapone is not an established inhibitor of either enzyme, so the risk is theoretical.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Theoretical inhibition of CYP2C19 and CYP3A4 by entacapone, which has not been clinically established.
What to do
No empirical dose change is needed. Follow the standard mavacamten echocardiographic monitoring of LVEF and Valsalva gradient and watch for heart failure symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Mavacamten?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is cleared by CYP2C19 and CYP3A4, and increased exposure can excessively reduce ejection fraction and cause heart failure. Entacapone is not an established inhibitor of either enzyme, so the risk is theoretical.
How serious is the interaction between Carbidopa-entacapone-levodopa and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Follow the standard mavacamten echocardiographic monitoring of LVEF and Valsalva gradient and watch for heart failure symptoms.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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