Drug interactions
Carbidopa-entacapone-levodopa + Ropinirole
Severity: Moderate
Carbidopa-entacapone-levodopa and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase dopaminergic stimulation and are often combined deliberately in Parkinson's disease. Together they can increase dyskinesia, hallucinations, impulse control disorders, somnolence and orthostatic hypotension.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Additive dopaminergic effects of levodopa conversion to dopamine and direct D2/D3 receptor agonism.
What to do
Titrate gradually and monitor for dyskinesia, psychosis, impulse control behaviors and daytime sleepiness. Reduce the levodopa or ropinirole dose if these emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Ropinirole?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase dopaminergic stimulation and are often combined deliberately in Parkinson's disease. Together they can increase dyskinesia, hallucinations, impulse control disorders, somnolence and orthostatic hypotension.
How serious is the interaction between Carbidopa-entacapone-levodopa and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate gradually and monitor for dyskinesia, psychosis, impulse control behaviors and daytime sleepiness. Reduce the levodopa or ropinirole dose if these emerge.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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