Drug interactions
Carbidopa-entacapone-levodopa + Scopolamine
Severity: Minor
Carbidopa-entacapone-levodopa and Scopolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is a centrally active anticholinergic that may cause confusion, hallucinations and delayed gastric emptying, potentially affecting levodopa absorption and tolerability. Effects may be less pronounced with the transdermal patch.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Scopolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Antimuscarinic delay of gastric emptying may increase gastric degradation of levodopa, with additive central anticholinergic effects.
What to do
Monitor for confusion, hallucinations and changes in motor control, and use the lowest effective scopolamine dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Scopolamine
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Scopolamine?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Scopolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Scopolamine is a centrally active anticholinergic that may cause confusion, hallucinations and delayed gastric emptying, potentially affecting levodopa absorption and tolerability. Effects may be less pronounced with the transdermal patch.
How serious is the interaction between Carbidopa-entacapone-levodopa and Scopolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations and changes in motor control, and use the lowest effective scopolamine dose.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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