Drug interactions
Carbidopa-entacapone-levodopa + Terazosin
Severity: Moderate
Carbidopa-entacapone-levodopa and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension. Combined with the alpha-blocker terazosin, which also causes postural hypotension, the blood pressure lowering may be additive, especially at treatment start or after dose increases.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from dopaminergic vasodilation and alpha-1 adrenergic blockade.
What to do
Check orthostatic blood pressure when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension appears. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Terazosin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension. Combined with the alpha-blocker terazosin, which also causes postural hypotension, the blood pressure lowering may be additive, especially at treatment start or after dose increases.
How serious is the interaction between Carbidopa-entacapone-levodopa and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension appears. Advise patients to rise slowly.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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